When Nighttime Leg Cramps Signal Something More Serious

Waking up with a sharp, tightening pain in your calf or foot is more common than most people realize. These sudden, involuntary contractions—known as nighttime leg cramps—can strike without warning and jolt you out of sleep.
Most of the time, they’re harmless, caused by dehydration, muscle fatigue, or even awkward sleeping positions. But in some cases, they can be a warning sign of something more serious.

When to Worry

If leg cramps happen more than three times a week, last longer than a few minutes, or cause lingering soreness, it’s worth talking to your doctor.
Cramps accompanied by swelling, numbness, or weakness could point to circulatory or nerve problems, including:

• Peripheral artery disease (PAD)

• Kidney or electrolyte issues

• Diabetes-related neuropathy

Certain medications—like diuretics, statins, and beta-blockers—can also increase cramping by affecting muscle and fluid balance.

Read Part 2